Nature Signaling Update News and reviews about the latest in cell signaling research, brought to you by Nature Publishing Group. http://www.signaling-gateway.org/update/ weekly 1 2003-06-20T20:00+00:00 Nature Signaling Update http://www.signaling-gateway.org/slices/logo_ucsd_sig.gif http://www.signaling-gateway.org/update/ Featured Article: Toll-like receptors: Less is more http://www.signaling-gateway.org/update/featured/ Proteolytic cleavage of the Toll-like receptor TLR9 creates a functional receptor that is retained at intracellular endolysosome compartments. Selected Update: Calcium: An effective get-together http://www.signaling-gateway.org/update/updates/200811/nrm2540.html The ER transmembrane protein STIM1 (stromal interaction molecule-1) assembles and opens the ORAI1 tetrameric ion channel. Selected Update: Lipid metabolism: Treasure hunt in fat http://www.signaling-gateway.org/update/updates/200811/nrm2533.html The adipose tissue-derived hormone palmitoleate enhances insulin signaling in muscle cell lines by inducing insulin-stimulated AKT phosphorylation, and suppresses inflammatory alterations in adipose tissue. Selected Update: Tumorigenesis: Keeping a watchful eye http://www.signaling-gateway.org/update/updates/200811/nrc2530.html Loss of IKKalpha (inhibitor of nuclear factor kappaB kinase-alpha) upregulates EGFR signaling and contributes to the development of squamous cell carcinoma of the skin. Research Library: Scaffolding function of PAK in the PDK1–Akt pathway http://www.nature.com/doifinder/10.1038/ncb1795 Research Library: The miR-15a—miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities http://www.nature.com/doifinder/10.1038/nm.1880 Research Library: A quantitative model of transcription factor–activated gene expression http://www.nature.com/doifinder/10.1038/nsmb.1500 UCSD-Nature Molecule Pages: Getting Started Guide http://www.signaling-gateway.org/molecule/hlp/author/MPUserGuide.pdf The UCSD-Nature Molecule Pages contains over 500 peer-reviewed and published review articles about the biological and biochemical properties of signaling proteins from transcription factors to membrane receptors. Please visit our new getting started guide for a quick overview of the anatomy of a published Molecule Page.