Research library: Structures
2008:
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December
letter
A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex
Bernard T. Kelly et al.
Nature 456, 976–979
(18 December 2008); doi:10.1038/nature07422
| Summary | Full Text (HTML / PDF) |
article
Structural insights into the Cyclin T1–Tat–TAR RNA transcription activation complex from EIAV
Kanchan Anand, Antje Schulte, Karin Vogel-Bachmayr, Klaus Scheffzek & Matthias Geyer
Nature Structural & Molecular Biology 15, 1287–1292
(December 2008); doi:10.1038/nsmb.1513
| Summary | Full Text (HTML / PDF) |
November
article
Gibberellin-induced DELLA recognition by the gibberellin receptor GID1
Kohji Murase, Yoshinori Hirano, Tai-ping Sun & Toshio Hakoshima
Nature 456, 459–463
(27 November 2008); doi:10.1038/nature07519
| Summary | Full Text (HTML / PDF) |
letter
Structural basis for gibberellin recognition by its receptor GID1
Asako Shimada et al.
Nature 456, 520–523
(27 November 2008); doi:10.1038/nature07546
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news and views
Plant Biology: Gibberellins close the lid
Peter Hedde
Nature 456, 455–456
(27 November 2008); doi:10.1038/456455a
| Full Text (HTML / PDF) |
article
Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5
Weijun Chen et al.
Nature Structural & Molecular Biology 15, 1213–1220
(November 2008); doi:10.1038/nsmb.1496
| Summary | Full Text (HTML / PDF) |
article
A nano-positioning system for macromolecular structural analysis
Adam Muschielok et al.
Nature Methods 5, 965–971
(November 2008); doi:10.1038/nmeth.1259
| Summary | Full Text (HTML / PDF) |
article
Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA
Vikas Chandra et al.
Nature 456, 350–356
doi:10.1038/nature07413
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letter
Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains
Tudor Moldoveanu, Kalle Gehring & Douglas R. Green
Nature 456, 404–408
(20 November 2008); doi:10.1038/nature07353
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letter
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
Rachel A. Hanna, Robert L. Campbell & Peter L. Davies
Nature 456, 409–412
(20 November 2008); doi:10.1038/nature07451
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news and views
Structural biology: Enzyme knocked for a loop
Ronald L. Mellgren
Nature 456, 337–338
(20 November 2008); doi:10.1038/456337a
| Full Text (HTML / PDF) |
article
The Janus-faced nature of the C2B domain is fundamental for synaptotagmin-1 function
Mingshan Xue, Cong Ma, Timothy K Craig, Christian Rosenmund & Josep Rizo
Nature Structural & Molecular Biology 15, 1160–1168
(November 2008); doi:10.1038/nsmb.1508
| Summary | Full Text (HTML / PDF) |
article
Structure of the guide-strand-containing argonaute silencing complex
Yanli Wang, Gang Sheng, Stefan Juranek, Thomas Tuschl & Dinshaw J. Patel
Nature 456, 209–213
(13 November 2008); doi:10.1038/nature07315
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letter
Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases
Pilar Redondo et al.
Nature 456, 107–111
(6 November 2008); doi:10.1038/nature07343
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article
Cortisone dissociates the Shaker family K+ channels from their β subunits
Yaping Pan et al.
Nature Chemical Biology 4, 708–714
(November 2008); doi:10.1038/nchembio.114
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news and views
To dislodge an enzyme from an ion channel, try steroids
Susy C Kohout & Ehud Y Isacoff
Nature Chemical Biology 4, 650–651
(November 2008); doi:10.1038/nchembio1108-650
| Full Text (HTML / PDF) |
October
letter
Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization
Masayuki Yamasaki, Wei Li, Daniel J. D. Johnson & James A. Huntington
Nature 455, 1255–1258
(30 October 2008); doi:10.1038/nature07394
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news and views
Structural biology: Serpins' mystery solved
James C. Whisstock & Stephen P. Bottomley
Nature 10, 1189–1190
(30 October 2008); doi:10.1038/4551189a
| Full Text (HTML / PDF) |
article
Activation of tyrosine kinases by mutation of the gatekeeper threonine
Mohammad Azam, Markus A Seeliger, Nathanael S Gray, John Kuriyan & George Q Daley
Nature Structural & Molecular Biology 15, 1109–1118
(October 2008); doi:10.1038/nsmb.1486
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article
BAX activation is initiated at a novel interaction site
Evripidis Gavathiotis et al.
Nature 455, 1076–1081
(23 October 2008); doi:10.1038/nature07396
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news and views
Apoptosis: Stabbed in the BAX
Douglas R. Green & Jerry E. Chipuk
Nature 455, 1047–1049
(23 October 2008); doi:10.1038/4551047a
| Full Text (HTML / PDF) |
article
Mapping a molecular link between allosteric inhibition and activation of the glycine receptor
Paul S Miller, Maya Topf & Trevor G Smart
Nature Structural & Molecular Biology 15, 1084–1093
(October 2008); doi:10.1038/nsmb.1492
| Summary | Full Text (HTML / PDF) |
article
Plasticity of the PAS domain and a potential role for signal transduction in the histidine kinase DcuS
Manuel Etzkorn et al.
Nature Structural & Molecular Biology 15, 1031–1039
(October 2008); doi:10.1038/nsmb.1493
| Summary | Full Text (HTML / PDF) |
brief communication
A torque component present in mitotic kinesin Eg5 revealed by three-dimensional tracking
Junichiro Yajima, Kana Mizutani & Takayuki Nishizaka
Nature Structural & Molecular Biology 15, 1119–1121
(October 2008); doi:10.1038/nsmb.1491
| Summary | Full Text (HTML / PDF) |
article
Tracking the structural dynamics of proteins in solution using time-resolved wide-angle X-ray scattering
Marco Cammarata et al.
Nature Methods 5, 881–886
(October 2008); doi:10.1038/nmeth.1255
| Summary | Full Text (HTML / PDF) |
September
article
Crystal structure of opsin in its G-protein-interacting conformation
Patrick Scheerer et al.
Nature 455, 497–502
(25 September 2008); doi:10.1038/nature07330
| Summary | Full Text (HTML / PDF) |
news and views
Structural Biology: A moving story of receptors
Thue W. Schwartz & Wayne L. Hubbell
Nature 455, 473–474
(September 2008); doi:10.1038/455473a;
| Full Text (HTML / PDF) |
article
Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains
Yusuke Sato et al.
Nature 455, 358–362
(18 September 2008); doi:10.1038/nature07254
| Summary | Full Text (HTML / PDF) |
article
SRP RNA controls a conformational switch regulating the SRP–SRP receptor interaction
Saskia B Neher, Niels Bradshaw, Stephen N Floor, John D Gross & Peter Walter
Nature Structural & Molecular Biology 15, 916–923
(September 2008); doi:10.1038/nsmb.1467
| Summary | Full Text (HTML / PDF) |
article
Structural basis for the activation of PPARγ by oxidized fatty acids
Toshimasa Itoh et al.
Nature Structural & Molecular Biology 15, 924–931
(September 2008); doi:10.1038/nsmb.1474
| Summary | Full Text (HTML / PDF) |
news and views
Insights into PPARγ from structures with endogenous and covalently bound ligands
Kendall W Nettles
Nature Structural & Molecular Biology 15, 893–895
(September 2008); doi:10.1038/nsmb0908-893
| Full Text (HTML / PDF) |
letter
Molecular architecture of native HIV-1 gp120 trimers
Jun Liu, Alberto Bartesaghi, Mario J. Borgnia, Guillermo Sapiro & Sriram Subramaniam
Nature 455, 109–113
(04 September 2008); doi:10.1038/nature07159
| Summary | Full Text (HTML / PDF) |
letter
Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B
Holger Rehmann et al.
Nature 455, 124–127
(04 September 2008); doi:10.1038/nature07187
| Summary | Full Text (HTML / PDF) |
progress
Structural comparisons of class I phosphoinositide 3-kinases
L. Mario Amzel et al.
Nature Reviews Cancer 8, 665–669
(September 2008); doi:10.1038/nrc2443
| Summary | Full Text (HTML / PDF) |
August
article
Gating the pore of P2X receptor channels
Mufeng Li, Tsg-Hui Chang, Shai D Silberberg & Kenton J Swartz
Nature Neuroscience 11, 883–887
(August 2008); doi:10.1038/nn.2151
| Summary | Full Text (HTML / PDF) |
review
Pseudoreceptor models in drug design: bridging ligand- and receptor-based virtual screening
Yusuf Tanrikulu & Gisbert Schneider
Nature Reviews Drug Discovery 7, 667–677
(August 2008); doi:10.1038/nrd2615
| Summary | Full Text (HTML / PDF) |
article
A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
Jemima Cordle et al.
Nature Structural & Molecular Biology 15, 849–857
(August 2008); doi:10.1038/nsmb.1457
| Summary | Full Text (HTML / PDF) |
letter
The pathogen protein EspFU hijacks actin polymerization using mimicry and multivalency
Nathan A. Sallee et al.
Nature 454, 1005–1008
(21 August 2008); doi:10.1038/nature07170
| Summary | Full Text (HTML / PDF) |
letter
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU
Hui-Chun Cheng, Brian M. Skehan, Kenneth G. Campellone, John M. Leong & Michael K. Rosen
Nature 454, 1009–1013
(21 August 2008); doi:10.1038/nature07160
| Summary | Full Text (HTML / PDF) |
article
The structure of CCT–Hsc70NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin
Jorge Cuéllar et al.
Nature Structural & Molecular Biology 15, 858–864
(August 2008); doi:10.1038/nsmb.1464
| Summary | Full Text (HTML / PDF) |
letter
Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase
Dominique P. Frueh et al.
Nature 454, 903–906
(14 August 2008); doi:10.1038/nature07162
| Summary | Full Text (HTML / PDF) |
letter
Structural basis for the selectivity of the external thioesterase of the surfactin synthetase
Alexander Koglin et al.
Nature 454, 907–911
(14 August 2008); doi:10.1038/nature07161
| Summary | Full Text (HTML / PDF) |
news and views
Biochemistry: Fit for an enzyme
Shiven Kapur & Chaitan Khosla
Nature 454, 832–833
(14 August 2008); doi:10.1038/454832a
| Full Text (HTML / PDF) |
article
On the nature of partial agonism in the nicotinic receptor superfamily
Remigijus Lape, David Colquhoun & Lucia G. Sivilotti
Nature 454, 722–727
(7 August 2008); doi:10.1038/nature07139
| Summary | Full Text (HTML / PDF) |
brief communication
Molecular recognition of nitrated fatty acids by PPARγ
Yong Li et al.
Nature Structural & Molecular Biology 15, 865–867
(August 2008); doi:10.1038/nsmb.1447
| Summary | Full Text (HTML / PDF) |
perspective
Cooperativity in macromolecular assembly
James R Williamson
Nature Chemical Biology 4, 458–465
(August 2008); doi:10.1038/nchembio.102
| Summary | Full Text (HTML / PDF) |
July
article
Structure of a β1-adrenergic G-protein-coupled receptor
Tony Warne et al.
Nature 454, 486–491
(24 July 2008); doi:10.1038/nature07101
| Summary | Full Text (HTML / PDF) |
article
Structure of and influence of a tick complement inhibitor on human complement component 5
Folmer Fredslund et al.
Nature Immunology 9, 753–760
(July 2008); doi:10.1038/ni.1625
| Summary | Full Text (HTML / PDF) |
article
The binding sites for cocaine and dopamine in the dopamine transporter overlap
Thijs Beuming et al.
Nature Neuroscience 11, 780–789
doi:10.1038/nn.2146
| Summary | Full Text (HTML / PDF) |
review
Advances in bacterial promoter recognition and its control by factors that do not bind DNA
Shanil P. Haugen, Wilma Ross & Richard L. Gourse
Nature Reviews Microbiology 6, 507–519
(July 2008); doi:10.1038/nrmicro1912
| Summary | Full Text (HTML / PDF) |
article
Crystal structure of the ligand-free G-protein-coupled receptor opsin
Jung Hee Park, Patrick Scheerer, Klaus Peter Hofmann, Hui-Woog Choe & Oliver Peter Ernst
Nature 454, 183–187
(10 July 2008); doi:10.1038/nature07063
| Summary | Full Text (HTML / PDF) |
article
An autonomous CDR3δ is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by γδ T cells
Erin J Adams, Pavel Strop, Sunny Shin, Yueh-Hsiu Chien & K Christopher Garcia
Nature Immunology 9, 777–784
(July 2008); doi:10.1038/ni.1620
| Summary | Full Text (HTML / PDF) |
perspective
Insights into signaling from the β2-adrenergic receptor structure
Martin Audet & Michel Bouvier
Nature Chemical Biology 4, 397–403
(July 2008); doi:10.1038/nchembio.97
| Summary | Full Text (HTML / PDF) |
scientific report
Crucial structural role for the PH and C1 domains of the Vav1 exchange factor
Jonathan Rapley, Victor L J Tybulewicz & Katrin Rittinger
EMBO reports 9, 655–661
doi:10.1038/embor.2008.80
| Summary | Full Text (HTML / PDF) |
June
letter
Structural basis for EGFR ligand sequestration by Argos
Daryl E. Klein, Steven E. Stayrook, Fumin Shi, Kartik Narayan & Mark A. Lemmon
Nature 453, 1271–1275
(26 June 2008); doi:10.1038/nature06978
| Summary | Full Text (HTML / PDF) |
review
The septin family of GTPases: architecture and dynamics
Christine S. Weirich, Jan P. Erzberger & Yves Barral
Nature Reviews Molecular Cell Biology 9, 478–489
(June 2008); doi:10.1038/nrm2407
| Summary | Full Text (HTML / PDF) |
article
A structural link between inactivation and block of a K+ channel
Christian Ader et al.
Nature Structural & Molecular Biology 15, 605–612
(June 2008); doi:10.1038/nsmb.1430
| Summary | Full Text (HTML / PDF) |
article
Internal dynamics control activation and activity of the autoinhibited Vav DH domain
Pilong Li, Ilídio R S Martins, Gaya K Amarasinghe & Michael K Rosen
Nature Structural & Molecular Biology 15, 613–618
(June 2008); doi:10.1038/nsmb.1428
| Summary | Full Text (HTML / PDF) |
article
Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2
Thomas A Bowden et al.
Nature Structural & Molecular Biology 15, 567–572
(June 2008); doi:10.1038/nsmb.1435
| Summary | Full Text (HTML / PDF) |
news and views
Evil versus 'eph-ective' use of ephrin-B2
Benhur Lee, Zeynep Akyol Ataman & Lei Jin
Nature Structural & Molecular Biology 15, 540–542
(June 2008); doi:10.1038/nsmb0608-540
| Full Text (HTML / PDF) |
letter
An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway
Scott W. Rowlinson et al.
Nature Cell Biology 10, 740–747
(June 2008); doi:10.1038/ncb1737
| Summary | Full Text (HTML / PDF) |
article
Activity-dependent site-specific changes of glutamate receptor composition in vivo
Andreas Schmid et al.
Nature Neuroscience 11, 659–666
(June 2008); doi:10.1038/nn.2122
| Summary | Full Text (HTML / PDF) |
article
The central unit within the 19S regulatory particle of the proteasome
Rina Rosenzweig et al.
Nature Structural & Molecular Biology 15, 573–580
(June 2008); doi:10.1038/nsmb.14272
| Summary | Full Text (HTML / PDF) |
May
article
Proteasome subunit Rpn13 is a novel ubiquitin receptor
Koraljka Husnjak et al.
Nature 453, 481–488
(22 May 2008); doi:10.1038/nature06926
| Summary | Full Text (HTML / PDF) |
letter
Ubiquitin docking at the proteasome through a novel pleckstrin–homology domain interaction
Patrick Schreiner et al.
Nature 453, 548–552
(22 May 2008); doi:10.1038/nature06924
| Summary | Full Text (HTML / PDF) |
news and views
Cell Biology: Two hands for degradation
Yasushi Saeki & Keiji Tanaka
Nature 453, 460–461
(22 May 2008); doi:10.1038/453460a
| Full Text (HTML / PDF) |
article
Membrane-dependent signal integration by the Ras activator Son of sevenless
Jodi Gureasko et al.
Nature Structural & Molecular Biology 14, 452–461
(May 2008); doi:10.1038/nsmb.1418
| Summary | Full Text (HTML / PDF) |
article
Crystal structure of squid rhodopsin
Midori Murakami & Tsutomu Kouyama
Nature 453, 363–367
(15 May 2008); doi:10.1038/nature06925
| Summary | Full Text (HTML / PDF) |
news and views
Signal Transduction: The rhodopsin story continued
Gebhard F. X. Schertler
Nature 453, 292–293
(15 May 2008); doi:10.1038/453292a
| Full Text (HTML / PDF) |
April
article
Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA
Cai-Guang Yang et al.
Nature 452, 961–965
(24 April 2008); doi:10.1038/nature06889
| Summary | Full Text (HTML / PDF) |
article
Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain
Shangwei Hou, Rong Xu, Stefan H Heinemann & Toshinori Hoshi
Nature Structural & Molecular Biology 15, 403–410
(April 2008); doi:10.1038/nsmb.1398
| Summary | Full Text (HTML / PDF) |
brief communication
Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Qing Huai et al.
Nature Structural & Molecular Biology 15, 422–423
(April 2008); doi:10.1038/nsmb.1404
| Summary | Full Text (HTML / PDF) |
article
Isolation of an active step I spliceosome and composition of its RNP core
Sergey Bessonov, Maria Anokhina, Cindy L. Will, Henning Urlaub & Reinhard Lührmann
Nature 452, 846–850
(17 April 2008); doi:10.1038/nature06842
| Summary | Full Text (HTML / PDF) |
article
The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3
Stefan Veltel, Raphael Gasper, Elke Eisenacher & Alfred Wittinghofer
Nature Structural & Molecular Biology 15, 373–380
(April 2008); doi:10.1038/nsmb.1396
| Summary | Full Text (HTML / PDF) |
article
NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses
Kendall W Nettles et al.
Nature Chemical Biology 4, 241–247
(April 2008); doi:10.1038/nchembio.76
| Summary | Full Text (HTML / PDF) |
news and views
Fast-tracking steroid receptor crystallization
Sylvie Mader
Nature Chemical Biology 4, 226–227
(April 2008); doi:10.1038/nchembio0408-226
| Full Text (HTML / PDF) |
article
A nuclear receptor-like pathway regulating multidrug resistance in fungi
Jitendra K. Thakur et al.
Nature 452, 604–609
(3 April 2008); doi:10.1038/nature06836
| Summary | Full Text (HTML / PDF) |
news and views
Drug resistance: The fight against fungi
André Goffeau
Nature 452, 541–542
(3 April 2008); doi:10.1038/452541a
| Full Text (HTML / PDF) |
article
Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer
Gisela D Cymes & Claudio Grosman
Nature Structural & Molecular Biology 15, 389–396
(April 2008); doi:10.1038/nsmb.1407
| Summary | Full Text (HTML / PDF) |
March
letter
X-ray structure of a prokaryotic pentameric ligand-gated ion channel
Ricarda J. C. Hilf & Raimund Dutzler
Nature 452, 375–379
(20 March 2008); doi:10.1038/nature06717
| Summary | Full Text (HTML / PDF) |
article
Pyruvate kinase M2 is a phosphotyrosine-binding protein
Heather R. Christofk, Matthew G. Vander Heiden, Ning Wu, John M. Asara & Lewis C. Cantley
Nature 452, 181–186
(13 March 2008); doi:10.1038/nature06667
| Summary | Full Text (HTML / PDF) |
letter
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk et al.
Nature 452, 230–233
(13 March 2008); doi:10.1038/nature06734
| Summary | Full Text (HTML / PDF) |
article
A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic
Héctor Salazar et al.
Nature Neuroscience 11, 255–261
(March 2008); doi:10.1038/nn2056
| Summary | Full Text (HTML / PDF) |
February
review
Cellular cholesterol trafficking and compartmentalization
Elina Ikonen
Nature Reviews Molecular Cell Biology 9, 125–138
(February 2008); doi:10.1038/nrm2336
| Summary | Full Text (HTML / PDF) |
letter
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
Xin Liu et al.
Nature 451, 846–850
(14 February 2008); doi:10.1038/nature06546
| Summary | Full Text (HTML / PDF) |
review
Membrane lipids: where they are and how they behave
Gerrit van Meer, Dennis R. Voelker & Gerald W. Feigenson
Nature Reviews Molecular Cell Biology 9, 112–124
(February 2008); doi:10.1038/nrm2330
| Summary | Full Text (HTML / PDF) |
article
Crystal structure of the multifunctional Gβ5–RGS9 complex
Matthew L Cheever, Jason T Snyder, Svetlana Gershburg, David P Siderovski, T Kendall Harden & John Sondek
Nature Structural & Molecular Biology 15, 155–162
(February 2008); doi:10.1038/nsmb.1377
| Summary | Full Text (HTML / PDF) |
review
Membrane recognition by phospholipid-binding domains
Mark A. Lemmon
Nature Reviews Molecular Cell Biology 9, 99–111
(February 2008); doi:10.1038/nrm2328
| Summary | Full Text (HTML / PDF) |
January
review
Molecular architecture of the kinetochore–microtubule interface
Iain M. Cheeseman & Arshad Desai
Nature Reviews Molecular Cell Biology 9, 33–46
(January 2008); doi:10.1038/nrm2310
| Summary | Full Text (HTML / PDF) |
article
Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions
Xiaoyan Chen, Heli Liu, Ann H R Shim, Pamela J Focia & Xiaolin He
Nature Structural & Molecular Biology 15, 50–56
(January 2008); doi:10.1038/nsmb1350
| Summary | Full Text (HTML / PDF) |
review
Heterotrimeric G protein activation by G-protein-coupled receptors
William M. Oldham & Heidi E. Hamm
Nature Reviews Molecular Cell Biology 9, 60–71
(January 2008); doi:10.1038/nrm2299
| Summary | Full Text (HTML / PDF) |
article
Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase
Jianbo Diao, Ying Zhang, Jon M Huibregtse, Daoguo Zhou & Jue Chen
Nature Structural & Molecular Biology 15, 65–70
(January 2008); doi:10.1038/nsmb1346
| Summary | Full Text (HTML / PDF) |
brief communication
Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2
Margarita Malakhova et al.
Nature Structural & Molecular Biology 15, 112–113
(January 2008); doi:10.1038/nsmb1347
| Summary | Full Text (HTML / PDF) |
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